Profiling of Humoral Response to Influenza A(H1N1)pdm09 Infection and Vaccination Measured by a Protein Microarray in Persons with and without History of Seasonal Vaccination
Identifieur interne : 000847 ( Main/Exploration ); précédent : 000846; suivant : 000848Profiling of Humoral Response to Influenza A(H1N1)pdm09 Infection and Vaccination Measured by a Protein Microarray in Persons with and without History of Seasonal Vaccination
Auteurs : Elisabeth G. W. Huijskens [Pays-Bas] ; Johan Reimerink [Pays-Bas] ; Paul G. H. Mulder [Pays-Bas] ; Janko Van Beek [Pays-Bas] ; Adam Meijer [Pays-Bas] ; Erwin De Bruin [Pays-Bas] ; Ingrid Friesema [Pays-Bas] ; Menno D. De Jong [Pays-Bas] ; Guus F. Rimmelzwaan [Pays-Bas] ; Marcel F. Peeters [Pays-Bas] ; John W. A. Rossen [Pays-Bas] ; Marion Koopmans [Pays-Bas]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.
We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria®, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.
We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.
Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.
Url:
DOI: 10.1371/journal.pone.0054890
PubMed: 23365683
PubMed Central: 3554683
Affiliations:
- Pays-Bas
- Groningue (province), Hollande-Méridionale, Hollande-Septentrionale
- Amsterdam, Groningue, Rotterdam
- Université d'Amsterdam, Université de Groningue
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De Jong</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. 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W." last="Huijskens">Elisabeth G. W. Huijskens</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg</wicri:regionArea><wicri:noRegion>Tilburg</wicri:noRegion></affiliation></author><author><name sortKey="Reimerink, Johan" sort="Reimerink, Johan" uniqKey="Reimerink J" first="Johan" last="Reimerink">Johan Reimerink</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute of Public Health and the Environment, RIVM, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Mulder, Paul G H" sort="Mulder, Paul G H" uniqKey="Mulder P" first="Paul G. H." last="Mulder">Paul G. H. Mulder</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Amphia Academy, Amphia Hospital, Breda, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Amphia Academy, Amphia Hospital, Breda</wicri:regionArea><wicri:noRegion>Breda</wicri:noRegion></affiliation></author><author><name sortKey="Van Beek, Janko" sort="Van Beek, Janko" uniqKey="Van Beek J" first="Janko" last="Van Beek">Janko Van Beek</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute of Public Health and the Environment, RIVM, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Meijer, Adam" sort="Meijer, Adam" uniqKey="Meijer A" first="Adam" last="Meijer">Adam Meijer</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute of Public Health and the Environment, RIVM, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="De Bruin, Erwin" sort="De Bruin, Erwin" uniqKey="De Bruin E" first="Erwin" last="De Bruin">Erwin De Bruin</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute of Public Health and the Environment, RIVM, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Friesema, Ingrid" sort="Friesema, Ingrid" uniqKey="Friesema I" first="Ingrid" last="Friesema">Ingrid Friesema</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute of Public Health and the Environment, RIVM, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="De Jong, Menno D" sort="De Jong, Menno D" uniqKey="De Jong M" first="Menno D." last="De Jong">Menno D. De Jong</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Peeters, Marcel F" sort="Peeters, Marcel F" uniqKey="Peeters M" first="Marcel F." last="Peeters">Marcel F. Peeters</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg</wicri:regionArea><wicri:noRegion>Tilburg</wicri:noRegion></affiliation></author><author><name sortKey="Rossen, John W A" sort="Rossen, John W A" uniqKey="Rossen J" first="John W. A." last="Rossen">John W. A. Rossen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg</wicri:regionArea><wicri:noRegion>Tilburg</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>National Institute of Public Health and the Environment, RIVM, Bilthoven, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>National Institute of Public Health and the Environment, RIVM, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.</p></sec><sec><title>Methods</title><p>We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria®, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.</p></sec><sec><title>Results</title><p>We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.</p></sec><sec><title>Conclusions</title><p>Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jia, N" uniqKey="Jia N">N Jia</name></author><author><name sortKey="De Vlas, Sj" uniqKey="De Vlas S">SJ de Vlas</name></author><author><name sortKey="Liu, Yx" uniqKey="Liu Y">YX Liu</name></author><author><name sortKey="Zhang, Js" uniqKey="Zhang J">JS Zhang</name></author><author><name sortKey="Zhan, L" uniqKey="Zhan L">L Zhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ 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Boulianne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skowronski, Dm" uniqKey="Skowronski D">DM Skowronski</name></author><author><name sortKey="Hottes, Ts" uniqKey="Hottes T">TS Hottes</name></author><author><name sortKey="Mcelhaney, Je" uniqKey="Mcelhaney J">JE McElhaney</name></author><author><name sortKey="Janjua, Nz" uniqKey="Janjua N">NZ Janjua</name></author><author><name sortKey="Sabaiduc, S" uniqKey="Sabaiduc S">S Sabaiduc</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Groningue (province)</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Groningue</li><li>Rotterdam</li></settlement><orgName><li>Université d'Amsterdam</li><li>Université de Groningue</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Huijskens, Elisabeth G W" sort="Huijskens, Elisabeth G W" uniqKey="Huijskens E" first="Elisabeth G. W." last="Huijskens">Elisabeth G. W. Huijskens</name></noRegion><name sortKey="De Bruin, Erwin" sort="De Bruin, Erwin" uniqKey="De Bruin E" first="Erwin" last="De Bruin">Erwin De Bruin</name><name sortKey="De Jong, Menno D" sort="De Jong, Menno D" uniqKey="De Jong M" first="Menno D." last="De Jong">Menno D. De Jong</name><name sortKey="Friesema, Ingrid" sort="Friesema, Ingrid" uniqKey="Friesema I" first="Ingrid" last="Friesema">Ingrid Friesema</name><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><name sortKey="Meijer, Adam" sort="Meijer, Adam" uniqKey="Meijer A" first="Adam" last="Meijer">Adam Meijer</name><name sortKey="Mulder, Paul G H" sort="Mulder, Paul G H" uniqKey="Mulder P" first="Paul G. H." last="Mulder">Paul G. H. Mulder</name><name sortKey="Peeters, Marcel F" sort="Peeters, Marcel F" uniqKey="Peeters M" first="Marcel F." last="Peeters">Marcel F. Peeters</name><name sortKey="Reimerink, Johan" sort="Reimerink, Johan" uniqKey="Reimerink J" first="Johan" last="Reimerink">Johan Reimerink</name><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name><name sortKey="Rossen, John W A" sort="Rossen, John W A" uniqKey="Rossen J" first="John W. A." last="Rossen">John W. A. Rossen</name><name sortKey="Rossen, John W A" sort="Rossen, John W A" uniqKey="Rossen J" first="John W. A." last="Rossen">John W. A. Rossen</name><name sortKey="Van Beek, Janko" sort="Van Beek, Janko" uniqKey="Van Beek J" first="Janko" last="Van Beek">Janko Van Beek</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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